BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Epigenome Online Journals

One of the goals of the NIH Roadmap Epigenomics Project is to produce human reference epigenomes from normal , healthy individuals across a wide variety of cell lines, primary cells, and primary tissues. The project's data, which can be browsed and downloaded from the Human Epigenome Atlas, falls into five categories that explore various aspects of the epigenome and epigenomic state outcomes. Histone Modifications – Chromatin Immunoprecipitation Sequencing (ChIP-Seq) uses antibodies to recognize genome wide patterns of histone modifications DNA methylation – Whole genome Bisulfite-Seq, Reduced Representation Bisulfite-Seq (RRBS), Methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq), and Methylation-sensitive Restriction Enzyme Sequencing (MRE-Seq) identify DNA methylation across portions of the genome at varying resolution rates down to the basepair level. Chromatin Accessibility – DNase I hypersensitive sites Sequencing (DNase-Seq) uses the DNase I enzyme to identify regions within the genome that are available or accessible. Gene expression – RNA-Seq arrays and expression arrays define levels of expression or genes coding for proteins. Small RNA Expression- smRNA-Seq detects low non-coding RNA expression, mainly miRNAs. Reference epigenomes for healthy individuals will enable the second goal of the Roadmap Epigenomics Project, which is to examine epigenomic differences that occur in disease states such as Alzheimer's disease.   Related epigenomics journals: Epigenomics Journal, Medical Epigenetics Journal, Genetics and Epigenomics Journal, Epigenetics and Chromatin Journal, Environmental Epigenetics Journal, Epigenetics Journal.

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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