Abstract

Preparation and characterization of modified starch isolated from Amaranthus paniculatus Linn.

Author(s): Lalit Singh, Pankaj Kumar,Niranjan Kaushik, Sourav Sharma, Pradeep Kumar

A study has been carried out to investigate the binding and disintegrating properties ofmodified starch, isolated formAmaranthus paniculatus Linn (Amaranthaceae). (Amaranth starch) .After modifications of Amaranth starch (MAS) dissolution profiles were studied. Paracetamol (500mg) was used as amarker drug and dissolution data ofMAS comparedwith explotab (marketed modified potato starch) (ES) and potato starch (PS) in batches of 200. All the products met the requirement of in vitro parameters like uniformity of weight, assay, friability and hardness as per pharmacopoeial requirements. These product also conformthe dissolution specification of USP. The amount ofmodified Amaranth starch (MAS) required as binding and disintegrating agent was three fourth of the amount of maize and potato starch. Therefore modified Amaranth starch can be effectively used in tablet technology.