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Top Open Access Journals In Cell Migration

Synthetic extracellular matrices provide a structure in which cells are often exposed to specified physical and biological indications; however, there is no method of regulating single cells inside these matrices today to understand fundamental cell migration principles and identify conditions that promote or inhibit cell movement. Here, we present a technique for manipulating individual mammalian stem cells in defined synthetic hydrogels through selective optical activation of Rac. A visible laser was applied to guide the spatial migration of mammalian stem cells through Tyr-Arg-Gly-Asp-Ser (YRGDS) poly(ethylene glycol), PEG, hydrogel based networks combined with an adhesion peptide ligand. A genetically encoded photoactivatable Rac1 (PA-Rac) transfected the mesenchymal stem cells (MSCs). Rac may be a subfamily of Rho GTPases that plays a pivotal role in cell migration by stimulating actin polymerization. On exposure to light locally in defined regions of the cell, subcellular activation of the PARac occurs.  

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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