BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Molecular And Cellular Biology Scholarly Peer-review Journal

The KEAP1-NRF2 pathway is the key defensive reaction to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 shapes some portion of an E3 ubiquitin ligase, which firmly directs the movement of the interpretation factor NRF2 by focusing on it for ubiquitination and proteasome-subordinate corruption. In light of pressure, a mind boggling sub-atomic component encouraged by sensor cysteines inside KEAP1 permits NRF2 to get away from ubiquitination, collect inside the cell, and translocate to the core, where it can advance its cancer prevention agent translation program. Ongoing advances have uncovered that KEAP1 contains different pressure sensors and inactivation modalities, which together permit various cell contributions, from oxidative pressure and cell metabolites to dysregulated autophagy, to manage NRF2 action. This combination of the KEAP1-NRF2 framework into various cell flagging and metabolic pathways places NRF2 initiation as a basic administrative hub in numerous sickness phenotypes and proposes that the pharmaceutical balance of NRF2's cytoprotective movement will be gainful for human wellbeing in a wide scope of noncommunicable maladies.

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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