BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Kinome Profiling

In biology, the kinome of AN organism is that the set of macromolecule kinases in its ordering. Kinases are enzymes that catalyze phosphorylation reactions (of amino acids) and fall into many teams and families, e.g., those that phosphorylate the aminoalkanoic acid s amino acid and essential amino acid, those that phosphorylate aminoalkanoic acid and a couple of which can phosphorylate each, just like the MAP2K and GSK families. The term was initially utilized in 2002 by Gerard Manning and colleagues in twin papers analyzing the 518 human macromolecule kinases and thus the evolution of macromolecule kinases throughout eukaryotes different kinomes are determined for rice, many fungi, nematodes, and insects, ocean urchins, Dictyostelium discoideum, and thus the tactic of infection by mycobacterium. Though the primary sequence of kinases shows a considerable divergence between unrelated eukaryotes, variation within the motifs that are actually phosphorylated by eukaryotic kinases is much smaller. As kinases are a significant drug target and management purpose in cell actions, the kinome has conjointly been the target of enormous scale genomics with RNAi screens and of drug discovery efforts, particularly in cancer medicine. 

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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