BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Epigenome Scholarly Peer-review Journal

One of the goals of the NIH Roadmap Epigenomics Project is to produce human reference epigenomes from normal , healthy individuals across a wide variety of cell lines, primary cells, and primary tissues. The project's data, which can be browsed and downloaded from the Human Epigenome Atlas, falls into five categories that explore various aspects of the epigenome and epigenomic state outcomes. Histone Modifications – Chromatin Immunoprecipitation Sequencing (ChIP-Seq) uses antibodies to recognize genome wide patterns of histone modifications DNA methylation – Whole genome Bisulfite-Seq, Reduced Representation Bisulfite-Seq (RRBS), Methylated DNA Immunoprecipitation Sequencing (MeDIP-Seq), and Methylation-sensitive Restriction Enzyme Sequencing (MRE-Seq) identify DNA methylation across portions of the genome at varying resolution rates down to the basepair level. Chromatin Accessibility – DNase I hypersensitive sites Sequencing (DNase-Seq) uses the DNase I enzyme to identify regions within the genome that are available or accessible. Gene expression – RNA-Seq arrays and expression arrays define levels of expression or genes coding for proteins. Small RNA Expression- smRNA-Seq detects low non-coding RNA expression, mainly miRNAs.   Reference epigenomes for healthy individuals will enable the second goal of the Roadmap Epigenomics Project, which is to examine epigenomic differences that occur in disease states such as Alzheimer's disease.    Scholarly journals function as forums for introducing and presenting the latest research to be scrutinised, and thus criticizing existing research. Material usually takes the form of papers that present original research, summary posts, and reviews of the books. The term scholarly journal applies to all fields of scholarly publications  

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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