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Current opinion

, Volume: 17( 1)

Synthetic Organic Chemistry as a Positive Catalyst

George Thomas
Department of Organic Chemistry, University of London, London, England, United Kingdom

Received: November 24, 2022, Manuscript No. TSOC-22-81056; Editor assigned: November 28, 2022, PreQC No. TSOC-22-81056 (PQ); Reviewed: December 12, 2022, QC No. TSOC-22-81056; Revised: February 24, 2023, Manuscript No. TSOC-22-81056 (R); Published: March 03, 2023, 10.37532/0974-7516.2023.17(1).006

Citation: Thomas G. Synthetic Organic Chemistry as a Positive Catalyst. Org Chem Ind J. 2023;17(1):006.


Long before a fundamental knowledge of the related radical intermediates was achieved, radical based synthesis techniques like the Kolbe electrolysis and Hofmann lof fler Freytag reaction were found and developed. The development of novel techniques for radical generation in recent years, together with the decade’s long accumulation of reactivity data on radical species, has sparked an increase in the use of radical based methods in synthetic planning and execution. The production of nitrogen containing organic molecules, which are crucial for chemistry, biology, and the material sciences, can be achieved by addition processes using systems or Hydrogen Atom Transfer (HAT).


Organozides; Photoredox catalysis; Lithium alkylamides; Dehydrogenative; Tetrasubstituted alkenes


The concept of the molecule and the development of synthetic organic chemistry, often known as organic or chemical synthesis or simply synthesis, in the 19th century, are two of the most important scientific breakthrough in history. They enabled us to change matters form and comprehend matter at the molecular level. The emergence of other historical discoveries and inventions, such as modern medicine, the genetic code, the birth control pill, and biotechnology, was made possible by the atomic molecular theory, the ability of organic synthesis to replicate molecules found in nature and others like them, and the analytical techniques that developed before and after those seminal events. They also gave birth to new disciplines, including biochemistry, structural biology, chemical biology and materials science and nanotechnology. The creative nature of synthetic organic chemistry earned the discipline the reputation of a fine art and a precise science. It literally changed the world and benefited society in untold ways as it grew in power and impact over a period of almost two centuries. Thus, organic synthesis helped shape the polymers and plastics, agriculture, vitamins, cosmetics, diagnostics and other high tech industries.

The latter contribution brought old and mediaeval methods into the clarity and light of molecular medicine, emancipating them from the shadows of herbal formulas and alchemy. The ability of organic synthesis to unite structure and function is what has had such a significant impact on science and society.


Despite its characteristics, however, due mostly to a lack of knowledge and exposure, synthetic organic chemistry regrettably does not enjoy the level of popularity it merits among the general population. The phenomenal capabilities of organic synthesis, its enormous impact on science and society and its potential to make significant contributions to science and technology as we face the widespread issues of health, hunger and the environment could all be better projected by synthetic organic chemists and the media. The accidental synthesis of urea, an organic chemical that occurs naturally, from the inorganic product ammonium isocyanate can be used to date the beginning of organic synthesis to the first half of the 19th century.

This development signaled the beginning of a revolution in chemistry that would prove fundamental, along with the rational synthesis of acetic acid that followed shortly after. These developments allowed synthetic organic chemists to envision the molecular architecture of a molecule and create it in the lab using atoms or groups of atoms, together with the structure of the molecule, whose demystification had started around the same time. In the lab, similar molecules to those found in nature might be produced. It was quickly discovered that synthesis may change the components. Mauvine and then indigo were the first such compounds to be synthesized, which established the dye business. Aspirin, the first drug to be produced synthetically and in pure form, was introduced shortly after the pharmaceutical business had been formed. Since then, countless new medications and dyes have been created by these wildly profitable businesses that are still growing, improving our lives and keeping us in good health. In the interim, synthetic organic chemistry developed, broadened its application and entered new fields of molecular complexity and diversity, producing molecules that served all practical needs. Synthetic organic chemistry ubiquity and enabling characteristics are explained by its generality and scope. The process of complete synthesis and method development are all included in its practice. Total synthesis is the process of reproducing compounds that are found in nature and similar substances. 2 total syntheses has played a significant role as a locomotive to challenge the existing bounds and constraints of the art, 4 thereby pushing the envelope in terms of scope and efficiency, according to the history of the evolution of synthetic organic chemistry 3 to its current condition. Such campaigns continue to produce novel technology and techniques, particularly when the practitioner sets high standards for difficulty and inventiveness. Total synthesis is one of the objectives of the project, notwithstanding how crucial it is to the development of the art and science of organic synthesis. Its goal of providing precious but rare molecules for biological research is just as crucial, if not more so. Additionally, once a method for synthesizing the parent natural product has been established, complete synthesis can be used to create unique, otherwise unobtainable varieties for biological testing. Such research initiatives nearly always result in therapeutic candidates that are more desirable than the original chemical due to superior biopharmaceutical profiles and simpler, hence simpler to synthesize structures.

The history of the birth control pill serves as a prime illustration of this aspect of synthesis. The birth control pill was not made widely available until the 1950’s, when synthesis made it possible to transform the abundant plant steroid diosgenin into the active but scarce components of contraceptives.


The development of antibody drug conjugates, a novel paradigm for drug delivery, provides a further, more contemporary example. Cancer treatments that are targeted and personalized which need for uncommon, extremely potent cytotoxic organic substances or their analogues that serve as payloads are created easily accessible through synthesis as well as research and development of new synthetic techniques are clearly facilitating for people who produce molecules. New ideas resulting from these efforts strengthen the synthesis arts instruments.

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Organic Chemistry: An Indian Journal received 565 citations as per Google Scholar report

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