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Utility of s-triazine nucleus in the synthesis of novel heterocyclic systems as potential antibacterial agents

Author(s): Kishor Kapadia, Yogesh Prajapati, Hiral Patel, Pankit Solankee, Sejal Solankee, Anjani Solankee

Chalcones, 2,4-bis-(4'-fluorophenylamino)-6-[4'-{3'’-(substituted phenyl)- 2'’-propenon-1’’-yl}phenylamino]-s-triazine (6a-f) have been prepared from ketone (5) on treatmentwith different aromatic aldehydes. These chalcones (6a-f) on cyclisation with guanidine nitrate and malono nitrile give the corresponding aminopyrimidine (7a-f) and cyanopyridine(8a-f) derivatives respectively.All the synthesized compounds have been screened for their antibacterial activities against S.aureus (MTCC96), B.subtilis(MTCC441), E.coli (MTCC 443) and S.paratyphi-B (MTCC 733), using cup-plate agar diffusion method. The structures of these compounds have been established on the basis of spectral studies and elemental analysis.

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