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Synthetic Vaccines Made Out of Peptide

Author(s): Karim Junaid

All vaccines used to be made with live or attenuated microbes or parts of them. The utilisation of complete organisms, their components, or the biological process for vaccine manufacture, on the other hand, has a number of drawbacks. In such vaccinations, the inclusion of immunologically redundant biological components or biological contaminants could cause serious issues. The development of entirely synthetic peptide-based vaccinations could address all of the drawbacks of existing vaccines. However, immune responses are low when just minimum antigenic epitopes are used for vaccination. The use of an adjuvant can help address this problem, but it may also introduce new problems. We examine epitope and adjuvant design, as well as multi-epitope and nanoparticle-based vaccine techniques, in this quick overview of the present state of peptide-based vaccines. The disadvantages and benefits of peptide-based vaccinations are also discussed in this brief review. It discusses techniques for overcoming the synthetic vaccination strategy's flaws as well as potential avenues for its advancement.

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Citations : 565

Organic Chemistry: An Indian Journal received 565 citations as per Google Scholar report

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