All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and Potential Antibacterial Activity of Hydrazone Derivatives with Imidazo[1,2-a]pyridine support against Escherichia Coli.

Author(s): Souleymane Coulibaly

This work presents the synthesis and investigated the antibacterial activity of seventeen (17) hydrazone derivatives with imidazo[1,2-a] pyridine support (5a-q). These compounds were obtained by condensation between 2-hydrazino-3-nitroimidazo[1,2-a] pyridine and aldehyde derivatives. The synthesized compounds were characterized by spectroscopic analyses (1H, 13C NMR), and High-Resolution Mass Spectrometry (HRMS). A preliminary antibacterial activity of the 5a-q compounds was determined on an E. coli strain by the disc diffusion method. The results showed that among the 17, 12-imidazo[1,2-a] pyridinehydrazone derivatives were potent with inhibition diameters between 8 mm and 11 mm. Compound 5a was more active with a diameter of 11 mm.


Share this       
Google Scholar citation report
Citations : 521

Organic Chemistry: An Indian Journal received 521 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs

Read More

Flyer
Global Tech Summit