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Synthesis and biological screening of 1-N-2'-(3'-methylbutanoicacid)-2-phenyl-4-arylidine-5-oxo-imidazolines

Author(s): C.M.Pandit, P.V.Bhatt, M.K.Pandya2, D.M.Purohit

1-N-2'-(3'-Methylbutanoicacid)-2-phenyl-4-arylidine-5-oxo-imidazolines (3a-j) have been synthesized by the condensation of L-valine with different oxazolones. The products have been assayed for their antimicrobial scrrening against Gram+ve and Gram-ve bacteria. Some of the products showed moderate activity compared with known standard drug viz. penicillin at same concentration 50µg/ml. The structure of the products have been elucidated by 1H NMR, IR,Mass spectral data.

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