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Synthesis and Antimicrobial Activity Evaluation of Some New Thiadiazinone and Thiadiazepinone Derivatives Bearing Sulfonamide Moiety

Author(s): Hany MM Dalloul*, Khaled A El-Nwairy, AZ Shorafa and Ahmed S Abu Samah

A new series of novel functionalized 1, 3, 4-thiadiazin-5-ones and 1, 3, 4-thiadiazepin-5-ones bearing sulfonamide moieties by 1, 3-dipolar cyclocondensation reaction of nitrilimines with α-mercaptoesters and mercaptosuccinic acid respectively. The structures of the newly prepared compounds were elucidated by spectral methods (IR, 1H-NMR, 13C-NMR and MS spectroscopy) and elemental analysis. The synthesized compounds were examined for their antimicrobial activity. Some of these compounds showed significant antimicrobial activity toward tested microbes.

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