All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis and Antimicrobial Activity Evaluation of Some New Thiadiazinone and Thiadiazepinone Derivatives Bearing Sulfonamide Moiety

Author(s): Hany MM Dalloul*, Khaled A El-Nwairy, AZ Shorafa and Ahmed S Abu Samah

A new series of novel functionalized 1, 3, 4-thiadiazin-5-ones and 1, 3, 4-thiadiazepin-5-ones bearing sulfonamide moieties by 1, 3-dipolar cyclocondensation reaction of nitrilimines with α-mercaptoesters and mercaptosuccinic acid respectively. The structures of the newly prepared compounds were elucidated by spectral methods (IR, 1H-NMR, 13C-NMR and MS spectroscopy) and elemental analysis. The synthesized compounds were examined for their antimicrobial activity. Some of these compounds showed significant antimicrobial activity toward tested microbes.


Share this