All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


New Biotechnological Methods for Producing Therapeutic Compounds (Usnic, Stictic and Norstictic Acids) by Cell Immobilization of the Lichen Cladonia substellata Vainio

Author(s): Martins MCB, Lima MJG, Santiago R, Buril MLL, Pereira EC, Legaz ME, Vicente C, and Silva NH

The aim of this paper is related to the modifications of the most usual method for producing USN and others bioactive compounds by the lichen Cladonia substellata to rationalize ecologically the provision of those at large scale. Different cell immobilization systems were assayed, using NaOAc as biosynthetic precursor at different concentrations. The introduced new systems to the most usual, consisting of the static incubation of immobilizates, were bioreactors in rotary movement and in continuous flow of precursor. They clearly enhance the production of USN. In addition, the kind of immobilization system can vary the content of produced metabolites. The occurrence of reduced USN and the occurrence of both NTI and STI acids in the cell washes were correlated. In this way, the modification of immobilization technique leads to highest production of these metabolites, and to a better use of the precursor, but it does not show any significant influence on the production of accessory and/or degraded compounds of the chemical species. On the basis of our results, USN and other compounds from C. substellata were produced in substantial amounts by kaolinite-immobilized continuous flow system and, in a general way, at a concentration of 10.0 mM, using NaOAc as precursor.

Share this       

Select your language of interest to view the total content in your interested language

Table of Contents

Google Scholar citation report
Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • Euro Pub

Read More

Recommended Conferences

26th World Congress on Biotechnology

Prague, Czech Republic

27th World Congress on Biotechnology

Prague, Czech Republic

27th Global Congress on Biotechnology

Paris, France

27th European Biotechnology Congress

Rome, Italy
Global Tech Summit