Methane Sulphonic Acid Catalyzed Efficient Protocol for Synthesis of 2-Hydroxy Chalcones

Author(s): Ramesh G, Sunil J and Pramod K

Methane sulphonic acid was found an efficient catalyst for synthesis of 2’-hydroxy chalcone via aldol condensation of 2-hydroxy acetophenone and substituted benzaldehyde. The merits of this protocol are efficient, eco-friendly, and inexpensive catalyst, short reaction time, high yield, and easy workup procedure. The catalyst is also well work with electron donating as well as electron with drawing group present aromatic ring. The structures of products were confirmed by melting point, IR, and 1H NMR.

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