Imidazole-Based Pharmaceutical Molecules are Synthesized Using the Van Leusen Imidazole SynthesisAuthor(s): George Bell*
One of the most significant and common heterocycles in medicinal chemistry is imidazole, along with its derivatives. Due to their distinctive structural characteristics, these compounds exhibit a wide range of major pharmacological or biological activities, and pharmaceutical companies routinely research and employ them to create new medications. Due to its advantages, the van Leusen reaction based on tosyl Methylisocyanides (TosMICs) is one of the most suitable methods for synthesizing imidazole based medicinal molecules. In this paper, we review recent developments in the chemical synthesis and bioactivity of imidazole-containing medicinal small molecules using the Van Leusen immobilization approach.