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Alzheimer's Disease and Stem Cell Therapies

Author(s): Harini Sree

Alzheimer's disease (AD) is a neurological illness that causes memory loss and cognitive impairment as it progresses. Synaptic failure and an excessive accumulation of misfolded proteins cause it. Almost all advanced clinical trials on specific AD-related pathways have failed to date, owing to the loss of a huge number of neurons in the brains of Alzheimer's patients. Furthermore, the pharmacological candidates that are currently accessible intervene too late. With the advancement of stem cell technology and the transformation of these cells into various types of central nervous system neurons and glial cells, stem cells have enhanced their self-renewal, proliferation, differentiation, and recombination features. In animal models of Alzheimer's disease, stem cell therapy has proven to be effective. Preclinical trials on stem cell therapy for Alzheimer's disease have shown promise. Human clinical studies using cell replacement therapies, such as human embryonic stem cells or induced pluripotent stem cell–derived neural cells, are currently underway to treat individuals with Alzheimer's disease. However, many more steps must be done before stem cell therapy may be used to treat human Alzheimer's disease and associated disorders in the clinic. This research examines the pathogenesis of Alzheimer's disease and the potential applications of associated stem cells based on cell type.

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