Abstract

Intelligible and augmented influence of DL-�������¡-tocopheryl acetate on lipid peroxidation and antioxidant status in various rat tissues

Author(s): Shabnum Nabi, Anjum Ara, Shamim Jahan Rizvi

Exposure of cells to everyday wear and tear inside the body caused by the reactions essential for aerobic life leads to the formation of reactive oxygen species (ROS) that are associated with cytotoxicity. Vit-E is the natural most effective lipid soluble antioxidant, which protects biological membranes and lipoproteins fromoxidative stress. Therefore, the present study concentrates on the potency of Vit-E to reverse the changes caused by free radicals in Brain, Heart, Lung and Pancreas oxidative system. Swiss albino rats were orally administered with Vit-E (50mg / kg BW) alone via gavage, every other day for 12 days. The results revealed that treatment with Vit-E significantly reduced the oxidative changes in some parameters examined. Comparing the Vit-E supplemented group with the saline controls, no significant difference could be detected in brain, lung and heart SOD activities but pancreatic SOD level was found to be higher when compared to controls (p<0.02). TSH activity was found nonsignificant in all the tissues on comparing to controls. LPO was reversed in pancreas (p<0.001), but no change was detected in brain, lung and heart. CAT activities were seen to be higher in brain (p<0.05), but no change was analyzed in other tissues in comparison to controls. In conclusion oxidative stress, especially LPO may play an important role in tissue degeneration process and Vit-E may play an important role in eliminating oxidative damage as an effective antioxidant.