BioTechnology: An Indian Journal
ISSN (PRINT): 0974-7435

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Family Hypercholesterolemia Scholarly Peer-review Journal

 Familial hypercholesterolemia or FH is an inherited defect in how the body recycles LDL (bad) cholesterol. As a consequence, LDL levels in the blood remain very high – in untreated adults, above 190 milligrams per deciliter (mg/dL) of blood. People with FH are essentially born with high LDL cholesterol. Everyone’s cholesterol levels tend to rise with age. But those with FH have LDL levels that start high and go even higher over time Familial hypercholesterolemia (FH) is a common life-threatening genetic condition that causes high cholesterol. People with FH have a high amount of low-density lipoprotein (LDL) or “bad cholesterol” due to a mutation in one of the genes that control the way cholesterol is cleared by the body. As a result, cholesterol accumulates in the bloodstream and can ultimately build up in the walls of the arteries. Cholesterol build-up in the artery wall is called hardening of the arteries, or atherosclerosis, and can lead to problems such as heart attacks and strokes in young adults and even children. People with familial hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease at a young age. This condition occurs when excess cholesterol in the bloodstream is deposited on the inner walls of blood vessels, particularly the arteries that supply blood to the heart (coronary arteries). The abnormal build-up of cholesterol forms clumps (plaques) that narrow and harden artery walls. As the plaques get bigger, they can clog the arteries and restrict the flow of blood to the heart. The build-up of plaques in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack  

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