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Cell Migration Impact Factor:

Synthetic extracellular matrices provide a system in which cells are often subjected to specified physical and biological indications, but there is currently no method for regulating single cells inside these matrices to understand fundamental cell migration principles and identify conditions that promote or inhibit cell movement. Here, we present a technique for manipulating individual mammalian stem cells in defined synthetic hydrogels through selective optical activation of Rac. A visible laser was applied to guide the directional migration of mammalian stem cells into Tyr-Arg-Gly-Asp-Ser (YRGDS) poly(ethylene glycol), PEG, hydrogel based networks incorporated with an adhesion peptide ligand. A genetically encoded photoactivatable Rac1 (PA-Rac) transfected the mesenchymal stem cells (MSCs).Rac may be a subfamily of Rho GTPases that plays a pivotal role in cell migration by stimulating actin polymerization.  

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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