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Cancer Susceptibility

Cancer susceptibility is a complex genetic trait, and few cancers are a result of mutations in a single gene. To tease out the factors that increase risk, it is usually necessary to follow large numbers of people over many years. But the problem has become somewhat more tractable thanks to a combination of cheaper methods to sequence genomes and the development of advanced computational tools. Advanced tools and methods allow for the detection of subtle differences in the genetic makeup of individuals and help find variations that exacerbate—or mitigate—risk. Untangling how the environment impacts the risk of cancer is even more daunting than charting the complex effects of our genes. For example, all life on earth must cope with constant exposure to DNA damage from sources such as ultraviolet light from the sun, X-rays and various chemicals, all of which cause mutations. But several research areas promise to uncover the roles of important environmental exposures in the coming years. The ultimate goal in the area of cancer susceptibility is to both understand the molecular basis of susceptibility and to predict who is most likely to develop certain cancers. There is also a need to understand what the specific risk factors are and which cancers are likely to be most aggressive so that steps can be taken to minimize risk and implement appropriate treatment. 

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Citations : 875

BioTechnology: An Indian Journal received 875 citations as per Google Scholar report

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