The latest innovation in stem cell therapies may serve as possible treatments for neurological disorders. There are expansive types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unique hope in treating many debilitating diseases. Now, Stem cell therapy in axonal demyelination and neurological disability (Specially MS) has been speedup by growth in animal models, as well as by clinical studies in human patients. A new path that promotes this procedure is tissue engineering, which uses synthesis of natural polymer that replicate extra cellular matrix for better response of body to grafted cells. The results of this new study ease the road for the utilization of stem cells for the treatment of MS. Furthermore, BMT plays a vital role in the induction of immune tolerance in organ transplantation. Bone marrow is a cushioned tissue, and is made up of hematopietic Stem Cells (HSCs), Mesenchymal Stem Cells (MSCs), and various blood cells. HSCs differentiate into common myeloid- and lymphoid-precursor cells and then terminally differentiate into erythrocytes, monocytes, platelets, neutrophils and other cells. MSCs can convert into not only mesoderm derived-cells such as adipocytes, osteoblasts, and osteoclasts, but also endodermand ectoderm-derived cells. Susumu Ikehara, improve in Leukemia Treatment with Bone Marrow Transplantation.