, Volume: 7( 1)
Scalable approach for the synthesis of 5-fluro-6-subtituted indoles
Abstract
An efficient approach towards the synthesis of indoles, the heterocyclic core of many standard 5HTreceptors agonists and pharmaceuticals used in many applications, via a modified Leimgruber-Batcho indole synthesis is presented. The process described herein is designed to suite the plant scale and is explained in multi kilogram quantities for 5-fluoro, 6-chloro indole, besides other substituted indoles that are reported with improved yields.
