Perspective

, Volume: 20( 1)

• View PDF
• Download PDF

Antimicrobial and Antifungal Activity of Palladium Rare Metal Complexes with Quinoline Derivative

²Department of Chemistry, Hemchandracharya North Gujarat University, Patan, Gujarat, India

*Correspondence:

HR Patel
Department of Chemistry, Khedbrahma Campus Hemchandracharya North Gujrat University, Vadali, India
E-mail:hareshpatel6900@yahoo.com

 

Introduction

The combination of some rare metal ions with biologically important kynurenic acid ligand to form coordination compound is an important area of current research. Less explored biologically important, kynurenic acid ligand is allowed to react with solution of some rare metal perchlorates and attempt has been made to synthesize solid kynurenic acid complexes. These kynurenic acid complexes are subjected to U.V-visible spectroscopy, IR spectroscopy, mass spectra, TGA analysis, elemental analysis etc. Antimicrobial activity of these complexes has been evaluated by standard methods and attempts have been made to correlate structural characteristics with properties of these kynurenic acid complexes.

Description

Antibacterial activity

This part deals with the in vitro screening of newly prepared compounds for antibacterial activity [1,2]. The species S. aureus, E. coli, S. pyogenes and P. aeruginosa have been taken for the antibacterial activities. Agar-cup method was employed for the in vitro screening for antibacterial activity [3-5]. The results of the compounds synthesized for antibacterial screening are mentioned in following Tables 1 and 2.

TABLE 1. Antibacterial activity of standard drugs.

TABLE 2. Antibacterial activity of kynurenic acid and its complexes.

Comparison of antimicrobial activity of synthesized compounds with that of standard antimicrobial drugs reveals that the complexes show moderate to good activity against all four bacterial strains, however by and large lower than the standard [6].

Antifungal activity

This part deals with the in vitro screening of newly prepared complexes for antibacterial activity [7]. The species C. albicans, A. niger, A. clavatus have been taken for the antifungal activities. Agar-cup method was used for the in vitro screening for antifungal activity. The results of the compounds synthesized and taken for antifungal screening are mentioned in as under Tables 3 and 4.

TABLE 3. Antifungal activity of standard drugs.

TABLE 4. Antifungal activity of kynurenic acid and its complexes.

Comparison of antimicrobial activity of complexes with that of standard antimicrobial drugs reveals that the synthesized complexes show moderate to good activity against all three fungal strains; however, they are in no way better for the purpose in comparison with standard [8,9].

Conclusion

Kynurenic acid is an important biological molecule with important physiological functions. In order to peep into its biological role and also to understand its complexing tendency and to explore some biochemical properties of its complexes, in the present work, Complexes of kynurenic acid with palladium metal ion was prepared, characterized for structure and studied for catalytic as well as antimicrobial activities. These results were encouraging as this bio active kynurenic acid molecule has good tendency of complex formation, as well as excellent catalysis and has moderate antibacterial activities. At many places, they were found to be excellent catalysts that can enhance reaction rates for selected redox and C-C coupling type organic chemical reactions.

Acknowledgement

Authors thank to Hemchandracharya North Gujarat University, Patan, India for supply chemical, A grade glass were and wonderful laboratory provide. We are thankful to Central Instrumental Maintenance Facilities (CIMF) Laboratory Hemchandracharya North Gujarat University, Patan, India to facilities of Spectral analysis. We are thankful to Rajani laboratory Surat, India to facilities of antimicrobial and antifungal activity.

References

1. Bandyopadhyay P, Sathe M, Ponmariappan S, et al. Exploration of in vitro time point quantitative evaluation of newly synthesized benzimidazole and benzothiazole derivatives as potential antibacterial agents. Bioorg Med Chem Lett. 2011;21(24):7306-7309.

   [Crossref] [Google Scholar] [PubMed]

2. Cos P, Vlietinck AJ, Berghe DV, et al. Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’. J Ethnopharmacol. 2006;106(3):290-302.

   [Crossref] [Google Scholar] [PubMed]

3. Desjardins RE, Canfield CJ, Haynes JD, et al. Quantitative assessment of antimalarial activity in vitro by a semi-automated microdilution technique. Antimicrob Agents Chemother. 1979;16(6):710-718.

   [Crossref] [Google Scholar] [PubMed]

4. Moussa A, Noureddine D, Mohamed HS, et al. Antibacterial activity of various honey types of Algeria against Staphylococcus aureus and Streptococcus pyogenes. Asian Pac J Trop Med. 2012;5(10):773-776.

   [Crossref] [Google Scholar] [PubMed]

5. Al-kafaween MA, Hilmi AB, Al-Jamal HA, et al. Potential antibacterial activity of Yemeni Sidr honey against Pseudomonas aeruginosa and Streptococcus pyogenes. Anti-Infective Agents. 2021;19(4):51-65.

   [Crossref] [Google Scholar]

6. Panjwani N, Clark B, Cohen M, et al. Differential binding of P. aeruginosa and S. aureus to corneal epithelium in culture. Invest Ophthalmol Vis Sci. 1990;31(4):696-701.

   [Google Scholar] [PubMed]

7. Massoud R, Saffari H, Massoud A, et al. Screening methods for assessment of antibacterial activity in nature. In 4th International Conference on Applied Researches in Science and Engineering. 2020;1–11.
8. Kumar NS, Simon N. In vitro antibacterial activity and phytochemical analysis of Gliricidia sepium (L.) leaf extracts. J Pharmacogn Phytochem. 2016;5(2):131-133.

   [Google Scholar]

9. Aher PS, Shinde YS, Chavan PP. In vitro evaluation of antibacterial potential of Annona squamosa L. against pathogenic bacteria. Int J Pharm Sci Res. 2012;3(5):1457-1460.

   [Google Scholar]