Ultrasonic-Assisted Simple, Mild and Efficient One-Pot Four-ComponentSynthesis of Highly Functionalized Pyrroles

Author(s): Morteza Rouhania

The one-pot four-component reaction between isocyanide (1), dialkyl acetylene dicarboxylates (2) and five-membered cyclic imides such as succinimide or maleimide (3) was done to study the synthesis of highly functionalized pyrroles in attendance of ultrasound (sono-synthesis) and loss of ultrasound conditions (conventional method). The reaction speed was remarkably catalyzed with the aid of ultrasound irradiation. Moreover, this approach prepares multiple other benefits such as operational ease, higher yields and energy performance.

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