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The Thermal Analysis of Felodipine and Ramipril: Application to Quality Control

Author(s): Ali KA, Elham AT, Zainab MY and Manal MF

Thermal behaviour of Felodipine (FEL) and Ramipril (RAM) drugs was studied in drug substance, binary mixture and co-formulated tablets. Some thermal analysis methods such as thermogravimetric analysis (TGA), derivative thermogravimetry (DrTGA), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) were used to investigate the thermal behaviour of both drugs. The thermogravimetric data allowed the determination of different thermodynamic and kinetic parameters such as: Ea, ΔH, ΔS and ΔG. The drugs purity was found to be 99.88% and 99.92% for FEL and RAM, respectively. The simplicity, speed and low cost of the thermal analysis justify its application in the quality control of pharmaceutical drugs.

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