Abstract

Synthesis of various azetidinone and thiazolidinone derivatives from5-chloro- 3-methyl-2-(2�-aminothiazole-4�-yl) benzofuran and their biological activities

Author(s): Raga Basawaraj, Srikanth Patil, Ashok Patil, T.Vijaykumar, G.Parmeshwarappa

5-Chloro-3-methyl-2-acetylbenzofuran (1) has been prepared from5-chloro- 2-hydroxy acetophenone and chloroacetone, which on further bromination with bromine in acetic acid gave 5-chloro-3-methyl-2-bromoacetylbenzofuran (2). Compound (2) treated with thiourea to gave 5-chloro-3-methyl-2-(2- aminothiazol-4-yl)benzofuran (3). 5-Chloro-3-methyl-2-(2-aminothiazol-4- yl)benzofuran (3) upon treated with substituted aromatic aldehydes to gave the corresponding Schiff’s bases (4a-e) which on treatment with mercaptoacetic acid and chloroacetylchloride to furnished the title compounds. The structures of all these compounds were established on the basis of spectral and analytical data. The newly synthesized compounds were screened for antimicrobial and some selected compounds were screened for their antitubercular activity.