Synthesis of 3,4-dihydropyrano[c]chromene derivatives under catalyst-free conditions

Author(s): Barisha Wahlang, Porag Bora, Ghanashyam Bez

Given the importance of chromene moiety, which is an essential pharmacophore in many antimicrobial, antiviral, antivascular, antifungal, antioxidant, anti-inflammatory, estrogenic, anticancer and anti-HIVagents, development of environmentally benign and practically simpler methods are highly desirable. Unlike many base catalyzed synthesis of 3,4- dihydropyrano[3,2-c]chromenes bymulticomponent reaction of aldehydes, malononitrile, and 4-hydroxy coumarinwhich has potential to generatemany byproducts, we have reported herein a catalyst-free method so synthesize the same. Comparison of two-component and three-component strategy led us to conclude that three component reaction generated bis-coumarin as byproduct while two-component reaction did not give any side reaction.

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