Abstract
Synthesis and characterization of acylated combretastatin-A4 analogs
Author(s): Hari N.Pati, Vijay S.SatamAseries of variously substituted 3,4-diphenyl-3-butene-2-ones (6a-6l) have been synthesized by condensation of phenylacetone and substituted aryl aldehydes. These ï¡,ï¢-unsaturated ketones possessing cis-stilbene core are structural analogs of combretastatin-A4, an effective anti-tumor agent. All the compounds have been characterized by 1H NMR, IR andmass spectroscopy and elemental analysis. The cis-configuration of the compounds in this series was ascertained by single crystal X-ray diffraction study of the representative compound (6e).
