Abstract

Synthesis and characterization of a systemic fungicide 5, 6-dihydro-2-methyl-1, 4-oxathiin-3-caboxanlido(Vitavax)

Author(s): Jyotsna Chauhan

blight on corn and wheat. It is very often used in combination with other fungicides such as Thiram or captan.Carboxin (alternative name Uniroyal D735, DCMO), was discovered and developed by Uniroyal International Division ofUniroyal Inc.USAunder the trade nameVitavax.Chemically it is 5,6-dihydro-2-methyl-1,4- oxathiin-3-caboxanlido with the formula C12H13NSO2 and molecular weight 235. The activity of fungicides is intimately related to its chemical structure. Knowledge about the chemical structure of a chemical is useful for the synthesis of new compounds with more specific actions and fewer adverse reactions, to increase/decrease the duration of action of the original drug or to get a more potent compound, to restrict the action to a specific system of the body and to reduce the adverse reactions, toxicity and other disadvantages associated. We can understand the basic chemical groups responsible for drug action[1]. Recently it has been observed that some of the fungicides are loosing their effects. So analogous compounds can be designed as substitute, if their structures are known.Arational approach to test these fungicides is to know the three dimensional structure of these compounds and macromolecular receptor sites as well as their molecular complex.