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Abstract

Synthesis and biological screening of 1-N-{4'-[(4",4"'-difluoro diphenyl)-methyl]-piperazine-1'-yl}-4-arylidene-2-(4""-methoxyphenyl)-5-oxo-imidazolines

Author(s): M.D.Savaliya, J.G.Dobaria, V.V.Bhuva, D.M.Purohit

1-N-{4'-[(4",4"'-difluorodiphenyl)-methyl]-piperazine-1'-yl}-4-arylidene-2- (4""-methoxy phenyl)-5-oxo-imidazolines (3a-3j) have been synthesized by the condensation of 1-amino-4-[(4',4"-difluorodiphenyl)-methyl]-piperazine with different oxazolones. The products have been assayed for their antimicrobial screening against Gram+ve, Gram–ve becteria and fungi. Some of the products showedmoderate activity compare with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and greseofulvin at same concentration 50ìg/ml. The structures of the products have been elucidated by IR, 1HNMR, Mass spectral data and elemental analysis.


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Organic Chemistry: An Indian Journal received 565 citations as per Google Scholar report

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