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Synthesis and biological evaluation of 1,3,5-triazine based chalcones and their derivatives

Author(s): Kishor Kapadia, Hiral Patel, Yogesh Prajapati, Pankit Solankee, Sejal Solankee, Anjani Solankee

Chalcones, 2,4-bis-(4’-chlorophenylamino)-6-[4’-{3’’-(substituted phenyl/ 2’’’- thienyl/2’’’-furanyl/cinnamyl)-2’’-propenon-1’’-yl}phenyl amino]-striazines( 6a-d) have been prepared from ketone (5) based on s-triazine nucleus. These chalcones (6a-d) on cyclisation with guanidine nitrate in presence of alkali, malononitrile in presence of ammonium acetate and hydrazine hydrate in presence of glacial acetic acid give the corresponding aminopyrimidines (7a-d), cyanopyridines (8a-d) and acetylpyrazolines (9a-d) respectively. The structures of newely synthesized compounds have been confirmed on the basis of elemental analysis, IR and 1H NMR spectral data. They are also tested for their antibacterial activity.

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