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Abstract

Synthesis and biological activity of 2-[(2, 3-dimethyl phenyl) amino]benzonamide azetidine-2-ones

Author(s): Kashinath Noubade, G.M.Channamma, T.Vijay Kumar, Y.Rajendra Prasad, R.H.Udupi

The reaction of 2-[(2,3-dimethylphenyl) amino] ethyl benzoate (1) with hydrazine hydrate in dry benzene gave 2-[(2,3-dimethylphenyl) amino] benzocarbohydrazide (2). Compound (2) upon treatment with substituted aromatic aldehydes to furnished the corresponding schiff‘s base (3a-e) which on treatment with acetyl chloride / with phenyl acetyl chloride and triethylamine in presence of dry benzene afforded 2-[2,3-dimethylphenyl amino)-N‘-[2-oxo-4-(substituted phenyl) azetidine-1-yl]benzamide (4a-e) and 2-(2,3-dimethylphenyl amino)-N‘-[2-oxo-3-phenyl-4-(substituted phenyl) azetidine-1-yl] benzamide (5a-e). All newly synthesized compounds were characterised on the basis of IR, 1HNMR and mass spectral data.


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