Synthesis and antimicrobial activity of some new N’-(3-chloro-6-substituted benzo[b]thiophene-2-carbonyl)-substituted-2-oxo-2Hpyrano[2,3-b]quinoline-3-carbohydrazides

Author(s): Guruprasad B.Vibhutimath, Bennikallu Hire Mathada Mruthyunjayaswamy

Equimolar quantities of 3-chloro-6-substituted benzo[b]thiophene-2- carbohydrazides (1a-b) and diethylmalonate (2a) when refluxed in dry xylene for 10 hr afford ethyl 3-(2-(3-chloro-6-substitutedbenzo[b]thiophene- 2-carbonyl)hydrazinyl)-3-oxopropanoate (3a-b). These on further reaction with substituted-2-hydroxy-3-formyl quinolines (4a-j) yielded N’-(3-chloro- 6-substitutedbenzo[b]thiophene-2-carbonyl)substituted-2-oxo-2H-pyrano [2,3-b]quinoline-3-carbohydrazides (5a-j). Structures of the all the newly synthesized compounds were confirmed by elemental analysis and spectral data.All these compounds have been screened for their antibacterial activity against Gram+ve Staphylococcus aureus&Bacillus subtilus and Gram –ve Escherichia coli & K. pneumonia and antifungal activity against Aspergillus niger and Candida albicans.

Share this