Abstract

Synthesis and anti-microbial activity of some new 5-substituted-N1-[(1E)-(substituted-2-carboxo-1H-quinolin-3-yl)methylene]-3-phenyl-1H-indole-2-carbohydrzide derivatives

Author(s): Suliphaldevara Mathada Basavarajaiah, Bennikallu Hire Mathada Mruthyunjayaswamy

Indole and its derivatives occupied a unique place in the chemistry of nitrogen heterocyclic compounds, because of their varied biodynamic properties. New substituted indole Schiff bases 5-substituted-N1-[(1E)-(substituted- 2-carboxo-1H-quinolin-3-yl)methylene]-3-phenyl-1H-indole-2- carbohydrzides (3a-d) are synthesized by condensation of 5-Substituted-3- phenyl-2-carboxahydrazides (1a-b) and substituted 3-formyl-2-carboxo-1Hquinolines (2a-b) in presence of catalytic amount of the glacial acetic acid. These Schiff bases on further reacting with acetic anhydride/thioglycolic acid inDMF/FeCl3-AcOHand con sulphuric acid gives respective pyrrazoles (4a-d)/ thioazolidines (5a-d)/ 1, 3, 4-oxadiazoles (6a-d) and oxadiazines (7ad) indole and quinoline derivatives. All the above synthesized compounds are conformed by spectral data and elemental analysis. The newly synthesized compounds were screened for their antimicrobial activity.