Synthesis and anti-microbial activity of few derivatives of 2-mercapto-3-phenyl-quinazolin-4(3H)-one

Author(s): Amita Verma, Neetu Soni, Namrata Soni

2-Mercapto-3-phenyl-quinazolin-4(3H)-one have been prepared by the reaction between anthranilic acid and phenyl thiourea. The sodium salt of 2- mercapto-3-phenyl-quinazolin-4(3H)-one on condensing with substituted aroyl chloride yielded thioesters of 3-phenyl-quinazolin-4(3H)-one.All the synthesized thioesterswere screened for their antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis. Some of the compounds showed good activity by taking Norfloxacin as standard.

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