Synthesis and antimicrobial activity of 5-{4'-[(6''-aryl)-2''-hydroxyl-3'',4''-dihydro pyrimidine-4''-yl]-phenyl carbamido}/5-
{4'-[(6''-aryl)-2''-mercapto-3'',4''-dihydropyrimidine-4''-yl] phenyl carbamido} dibenz [b,f] azepines

V.N.Patolia; R.K.Kanpariya; J.G.Dobaria; D.M.Purohit

Organic Chemistry: An Indian Journal
ISSN (PRINT): 0974-7516

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Abstract

Synthesis and antimicrobial activity of 5-{4'-[(6''-aryl)-2''-hydroxyl-3'',4''-dihydro pyrimidine-4''-yl]-phenyl carbamido}/5- {4'-[(6''-aryl)-2''-mercapto-3'',4''-dihydropyrimidine-4''-yl] phenyl carbamido} dibenz [b,f] azepines

Author(s): V.N.Patolia, R.K.Kanpariya, J.G.Dobaria, D.M.Purohit

5-{4'-[(6''-Aryl)-2''-hydroxy-3'',4''-dihydro pyrimidine 4''-yl] phenyl carbami-do} diben [b,f] azepines (4ha-4hn); 5- {4'-[(6''-aryl)-2''-mercapto-3'',4''-dihydropyrimidine-4''-yl] phenyl carbamido}-dibenz [b,f] azepines (5ma-5mn) have been synthesised. The products have been assayed for their antimicrobial activities. Some of the products showedmoderate activity in comparisonwith known standard drugs.Viz ampicillin, chloramphenicol, norfloxacin and greseofulvin at same concentration 50 Ã¯ÂÂg./ml. Constitution of the products have been characterized by IR, 1HNMR, Mass spectral studies and elemental analyses.