Abstract

Synthesis and antimicrobial activity of 5-{4'-[(5"-aryl)-4", 5"-dihydro-1"-(H/acetyl/phenyl) pyrazole-3"-yl] phenyl carbamido}-dibenz [b.f] azepines

Author(s): V.N.Patolia, R.K.Kanpariya, V.P.Gohel, D.M.Purohit

5-{4'-[(5"-aryl)-4",5"-dihydro-1"-(H)-pyrazol 3"-yl] phenyl carbamido} - dibenz [b,f] azepines (4a-4n); 5-{4'-[(5"-aryl)-4", 5"- dihydro-1"-acetyl pyrazole-3''-yl] phenyl carbamido}-dibenz [b,f] azepines (5a-5n); 5-{4'-[(5"- aryl)-4",5"–dihydro-1''-phenyl pyrazole-3"-yl]-phenyl carbamido}- dibenz [b,f] azepines (6a-6n) have been synthesized. The products have been assayed for their antimicrobial activity againstGram+ve,Gram-ve bacteria and fungi. Antimicrobial activities of the products compare with known standard drugs.Viz ampicillin, chloramphenicol, norfloxacin and griseofulvin at same concentration 50 g/ml. The stractures of the products have been elucidated by IR, 1HNMR,Mass spectral data and elemental analysis.