Abstract

Synthesis and antimicrobial activity of 1-N-(arylideneamino)/1-N-(arylmethylamino)-4-[(4', 4"-difluorodiphenyl)-methyl]-piperazines

Author(s): M.D.Savaliya, J.G.Dobaria, D.M.Purohit

1-N-arylideneamino-4-[(4',4"-difluorodiphenyl)-methyl]-piperazines (3a-3j); 1-N-arylmethyl amino-4-[(4',4"-difluorodiphenyl)-methyl]-piperazines (4a- 4j) have been synthesized. The products have been assayed for their antimicrobial screening againstGram+ve,Gram–ve becteria and fungi. Some of the products showedmoderate activity compare with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and greseofulvin at same concentration 50ìg/ml. The structures of the products have been elucidated by IR, 1HNMR, Mass spectral data and elemental analysis.