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Abstract

Synthesis and antifungal activity of (Z)-3-chloromethylenethiochroman-4-ones

Author(s): Tian Wei, Ma Zheng-Yue, Yang Geng-Liang, Fang Bao-Ling, Wang Ge, Li Lin-Bo

A convenient and efficient procedure has been developed for the synthesis of (Z)-3-Chloromethylenethiochroman-4-ones and the chlorinationmethod has not reported before. The chlorination agent, reaction temperature, pressure and reaction time of the chlorination reactions were studied and the probable chlorination mechanism was conjectured. The structures of the novel compounds had been confirmed by 1H-NMR, MS, element analysis and IR spectrum. Their antifungal activity was tested by micro dilution broth susceptibility for ten kinds of fungi. These compounds exhibited potent antifungal activities toward tested fungi.


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Organic Chemistry: An Indian Journal received 565 citations as per Google Scholar report

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