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Synthesis and antibacterial activity of some Alpha,Beta-unsaturated aromatic ketones and their derivatives

Author(s): Kishor Kapadia, Pankit Solankee, Yogesh Prajapati, Hiral Patel, Sejal Solankee, Anjani Solankee

Chalcones, 2,4-bis-(phenylamino)-6-[4'-{3'’-(phenyl / substituted phenyl)- 2'’-propenon-1’’-yl} phenylamino]-s-triazines (6a-e) have been prepared from ketone (5) based on s-triazine nucleus. These chalcones (6a-e) on cyclisation with hydrazine hydrate in presence of glacial acetic acid and malononitrile in presence of ammonium acetate give the corresponding pyrazolines (7a-e) and cyanopyridines (8a-e) respectively.All the synthesized compounds have been screened for their antibacterial activity. The constitutions of newly synthesized compounds have been established on the basis of their elemental analysis, IR and 1H NMR spectral data.

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