Abstract
Synthesis and anti inflammatory activity of 2-substituted-[(n, ndisubstituted) - 1, 3-benzoxazol]-5-carboxamides.
Author(s): M.Reena1, G.Kiran, G.Rajyalakshmi, J.Venkateshwar Rao, M.SarangapaniA series of 2-substituted-[(N,N-disubstituted)1,3-benzoxazol]-5- carboxamides derivatives were synthesized by reaction of 2-substituted-5- carbomethoxy benzoxazole with different secondary amines. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H NMR) analysis.All these compounds were screened for anti-inflammatory activity using carrageenan induced rat pawedema method.All of these compounds exhibited significant activity. Among the tested compounds, Va, Vb and Ve were considered to have potent anti inflammatory activity and was comparable with standard.
