Super critical fluid extract of Angelica gigas Nakai promotes collagen synthesis in human dermal fibroblastAuthor(s): Sang Yo Byun, Dong Myung Kim, Mi Ae Yoo, Young Keun Song
The extract of Angelica gigas Nakai by supercritical CO2 promoted the expression of collagen synthesis-related proteins in human dermal fibroblast. The condition applied for the supercritical fluid extraction was 400 bar and 60ï°C. By the proteome expression profiling, both of type 1(ï¡-2) collagen chain precursor and prolyl 4-hydroxylasewere expressed 1.7 times more. The procollagen C-endopeptidase was also increased 1.5 times. Proteome analysis proved that Angelica gigas Nakai promoted proteome synthesis related to skin anti-aging in human dermal fibroblasts.