All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Studieswith arylhydrazono-3-oxopropanals: A novel route to synthesis of substituted pyrazoles, oxoalkanonitrile and glyoxalonitrile containing sulfa drugmoieties

Author(s): A.M.Hussein, I.S.Abdel Hafiz, E.A.Ishak, M.H.Elnagdi, A.A.Atalla

Coupling of enaminones (1) with diazonium salts gave the hydrazono propanals (3a-h). Compound (3) react with -bromoacetophenone or - chloroacetanilide to yield (5) and (8). These compounds were cyclized smoothly into (6) and (9) respectively. Reactions of phenylhydrazine gave diphenylhydrazones (10) which cyclized into arylazopyrazoles (11) in refluxing pyridine.However, reaction of (3c-f)with hydrazine hydrate afforded pyrazoles (12). Reactions of (3) with phenylhydrazine hydrochloride afforded (11). Finally, reaction of (3c) with hydroxylamine hydrochloride afforded the aldoxime (14) that on refluxing in pyridine gave (15) not (16).


Share this       
Google Scholar citation report
Citations : 565

Organic Chemistry: An Indian Journal received 565 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • ICMJE

View More

Flyer