Studies on acetylpyrimidine: A facil one�?�?�?�?�?�?�?�?pot synthesis of condensed pyrimidines

M.G.Assy; M.H.Sherif; Abd El-Galile E.Amr; Zainab M.R.Mohamed

Organic Chemistry: An Indian Journal
ISSN (PRINT): 0974-7516

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Abstract

Studies on acetylpyrimidine: A facil one�?�?�?�?�?�?�?�?pot synthesis of condensed pyrimidines

Author(s): M.G.Assy, M.H.Sherif, Abd El-Galile E.Amr, Zainab M.R.Mohamed

Cyclo addition of benzal acetophenone to mercaptopyrimidine (1) afforded thiopyranopyrimidine (5). Ethylglycinate (7a) reactedwith chloropyrimidine (6) to produce deazapurine (10) while ethylphenylglycinate (7b,c) yielded pyrrolopyrimidine (9a,b). The synthesis of pyrimidodiazpen (13) was achieved from the condensation reaction between compound (6) and hydrazine derivative (11). The synthesis of pyrimidoquinoline (16), pyridopyrimidine (21), (24) was also described.