Scalable approach for the synthesis of 5-fluro-6-subtituted indoles

Author(s): P.Samatha Reddy, Y.V.Krishna Reddy, G.Madhusudhan Reddy, Satish Nigam, G.Madhusudhan

An efficient approach towards the synthesis of indoles, the heterocyclic core of many standard 5HTreceptors agonists and pharmaceuticals used in many applications, via a modified Leimgruber-Batcho indole synthesis is presented. The process described herein is designed to suite the plant scale and is explained in multi kilogram quantities for 5-fluoro, 6-chloro indole, besides other substituted indoles that are reported with improved yields.

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