Reduction of ÃÂ¡-Amino acids to chiral amino alcohols with potassium borohydride and aluminumchlorideAuthor(s): Yu-Qing Cao, Fa-Yu Zhang, Shuai Nian
The formation of chiral amino alcohols by reduction of amino acids has been widely studied due to their important applications. á-Amino acids were reduced through KBH4/AlCl3 under mild or reflux reactions conditions , providing corresponding aminio alcohols in high yield and purity. It suggested that 1.4 equivalent of AlCl3 was adequate to reduce the amino acids to the corresponding â-amino alcohol. An improved, convenient procedure that reduces amino acids through KBH4/AlCl3 to the corresponding chiral amino alcohols in excellent yields under mild conditions has been found.