All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Quantification Of Atropine In Rat Plasma By Liquid Chromatography Tandem Mass Spectrometry

Author(s): Yong Chen, Xinli Wang, Huaixia Chen, Fengmei Han, Peng Du

An analytical method based on liquid chromatography coupled with electrospray ionization (ESI) ion trap tandem mass spectrometry detection has been developed and validated for the determination of atropine in rat plasma using anisodamine as the internal standard in selected reaction mornitoring (SRM) mode. The standard curve was linear in the range of 5 to 5000 ng/mL. The assay was specific, accurate, precise and reproducible. The method was employed in a pharmacokinetic study after a single oral gavage dose of 50 mg/kg atropine to six rats.


Share this       
Awards Nomination 20+ Million Readerbase

Table of Contents

Google Scholar citation report
Citations : 378

Analytical Chemistry: An Indian Journal received 378 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • ICMJE

View More

Flyer