Abstract

Process chemistry of 4, 6-dihydroxy-2-methylpyrimidine-A potential precursor in pharmaceutical and explosive industries

Author(s): R.S.Patil, P.M.Jadhav, S.Radhakrishnan, T.Soman

4,6-Dihydroxy-2-methylpyrimidine as an important precursor, findwidespread applications in the preparation of high explosives and medicinal valued products. The synthesis of 4,6-dihydroxy-2-methylpyrimidine has been carried out by the condensation of acetamidinium chloride and diethyl malonate in absolutemethanol and further acidified by hydrochloric acid. Process chemistry has been studied by using various alcohols, alkoxides and effect of reaction period. The role of process variables and parameters has been understood thoroughly and developed an economic process. Modified process yielded the productwithout compromising on its quality, which was confirmed by spectroscopic techniques and elemental analysis. Hence, the study finds its usefulness in the development of an economic process for the production of 4, 6-dihydroxy-2-methylpyrimidine.