Polyurethane Systems with Sophorolipid-Based Oligomers as Polyol ComponentsAuthor(s): Amelia Williams
The Ugi-azide is a four-component reaction for the synthesis of 1,5-Disubstituted Tetrazole(1,5-DST), which involves an aldehyde, various amines, isocyanides, and as an azide source the Trimethylsilylazide (TMSN3), in water as a solvent, with Tetradecyltrimethylammonium Bromide (TTAB) as a catalyst, which provides This method is a first step toward a 1,5 disubstituted tetrazole green chemistry synthesis. By utilising a vast substrate scope, a series of 1, 5-disubstituted tetrazole was synthesised, yielding yields ranging from 43% to 56%, which were then compared to yields produced with methanol as the solvent. Tetrazole derivatives have gotten a lot of interest as prime heterocycles because of their widespread use in industries including medicine, pharmacology, and photography, as well as their potential use as explosives and rocket propellant components due to their high energy characteristics. Because of their bioisosterism to carboxylic acid and amide moieties, and lipophilicity, which is potentially more beneficial when cell membrane is desiccated, 1, 5-disubstituted tetrazole moieties (1,5-DST) have been widely and successfully used in medicinal chemistry and drug design as anti-inflammatory (I), antiviral (i.e., HIV) (II), antibiotics (III), antiulcer (IV), anxiety (V), anti-tubercular (VI). The 1,3-dipolarcycloaddition reaction between nitriles and azides is the most popular way to get tetrazole derivatives.