Molecular Recognition In Present Scenario

Author(s): Abhay K.Srivastava, K.K.Singh, Shubhra Singh

Design and synthesis of supramolecular systems from the appropriate synthons through non covalent interactions is currently attracting the attention of chemists not only for their biological involvement but also for various technologically important applications such as molecular recognition, transport, biosensors, non linear optics and microelectronics etc. The self assembly of complementary fragments occurs through nature and plays and essential role in construction of biological superstructure. The small subunits bind together reversibly through weak, multiple noncovalent interactions. Recently, considerable efforts have been focused on the use of simple synthetic systems to probe the determinants of the natural self assembly. Indeed, a number of elegant organic self – assembling systems are now known. In the present communication a full range of noncovalent forces including π-π stacking, hydrogen bonding and hydrophobic interactions have been abstracted and described as recognition motifs.

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